COMPLERA vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. COMPLERA and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COMPLERA	MYSOLINE
Rating	72/100	74/100
Pharmacy pays	~$435.30 /30	~$2.89 /30
Type	RX	RX
Active ingredient	EMTRICITABINE AND RILPIVIRINE HYDROCHLORIDE AND TENOFOVIR DISOPROXIL FUMARATE	PRIMIDONE
Manufacturer	Gilead Sciences Inc	Valeant Pharm Intl
Dosage forms	Tablet	Tablet
Drug class	—	Anti-Epileptic Agent
Boxed warning	Boxed warning	None
Treats	—	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

complera mysoline

Rating

72/100

74/100

Pharmacy pays

~$435.30 /30

~$2.89 /30

Type

Active ingredient

EMTRICITABINE AND RILPIVIRINE HYDROCHLORIDE AND TENOFOVIR DISOPROXIL FUMARATE

PRIMIDONE

Manufacturer

Gilead Sciences Inc

Valeant Pharm Intl

Dosage forms

Tablet

Drug class

—

Anti-Epileptic Agent

Boxed warning

None

Treats

—

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is better-rated, Complera or Mysoline?

By our independent rating, Mysoline scores higher — 3.7 vs 3.6 out of 5 for Complera. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Complera or Mysoline?

Mysoline costs pharmacies less to acquire — about $2.89 vs $435.30 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Complera and Mysoline?

Complera contains Emtricitabine and Rilpivirine Hydrochloride and Tenofovir Disoproxil Fumarate, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.