COMPLERA vs CUPRIMINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. COMPLERA and CUPRIMINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COMPLERA	CUPRIMINE
Rating	72/100	74/100
Pharmacy pays	~$435.30 /30	—
Type	RX	RX
Active ingredient	EMTRICITABINE AND RILPIVIRINE HYDROCHLORIDE AND TENOFOVIR DISOPROXIL FUMARATE	PENICILLAMINE
Manufacturer	Gilead Sciences Inc	Valeant Pharm Intl
Dosage forms	Tablet	Capsule
Drug class	—	Antirheumatic Agent
Boxed warning	Boxed warning	Boxed warning
Treats	—	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

complera cuprimine

Rating

72/100

74/100

Pharmacy pays

~$435.30 /30

—

Type

Active ingredient

EMTRICITABINE AND RILPIVIRINE HYDROCHLORIDE AND TENOFOVIR DISOPROXIL FUMARATE

PENICILLAMINE

Manufacturer

Gilead Sciences Inc

Valeant Pharm Intl

Dosage forms

Tablet

Capsule

Drug class

—

Antirheumatic Agent

Boxed warning

Treats

—

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Frequently asked questions

Which is better-rated, Complera or Cuprimine?

By our independent rating, Cuprimine scores higher — 3.7 vs 3.6 out of 5 for Complera. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Complera and Cuprimine?

Complera contains Emtricitabine and Rilpivirine Hydrochloride and Tenofovir Disoproxil Fumarate, while Cuprimine contains Penicillamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.