COMPAZINE vs TRIFLUOPERAZINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. COMPAZINE and TRIFLUOPERAZINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COMPAZINE	TRIFLUOPERAZINE HYDROCHLORIDE
Rating	70/100	New
Pharmacy pays	~$5.22 /30	~$22.02 /30
Type	RX	RX
Active ingredient	PROCHLORPERAZINE MALEATE	TRIFLUOPERAZINE HYDROCHLORIDE
Manufacturer	Glaxosmithkline	Duramed Pharms Barr
Dosage forms	Capsule, extended release, Tablet, Suppository	Tablet
Drug class	Phenothiazine	Phenothiazine
Boxed warning	None	None
Treats	Anxiety Disorders, Dementia, Nausea	Anxiety Disorders, Psychotic Disorders, Schizophrenia

compazine trifluoperazine hydrochloride

Rating

70/100

New

Pharmacy pays

~$5.22 /30

~$22.02 /30

Type

Active ingredient

PROCHLORPERAZINE MALEATE

TRIFLUOPERAZINE HYDROCHLORIDE

Manufacturer

Glaxosmithkline

Duramed Pharms Barr

Dosage forms

Capsule, extended release, Tablet, Suppository

Tablet

Drug class

Phenothiazine

Boxed warning

None

Treats

Anxiety Disorders, Dementia, Nausea

Anxiety Disorders, Psychotic Disorders, Schizophrenia

Frequently asked questions

Which is cheaper, Compazine or Trifluoperazine Hydrochloride?

Compazine costs pharmacies less to acquire — about $5.22 vs $22.02 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Compazine and Trifluoperazine Hydrochloride?

Compazine contains Prochlorperazine Maleate, while Trifluoperazine Hydrochloride contains Trifluoperazine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.