COMPAZINE vs PHENERGAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. COMPAZINE and PHENERGAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COMPAZINE	PHENERGAN
Rating	70/100	New
Pharmacy pays	~$5.22 /30	~$1.53 /30
Type	RX	RX
Active ingredient	PROCHLORPERAZINE MALEATE	PROMETHAZINE HYDROCHLORIDE
Manufacturer	Glaxosmithkline	Pharmobedient
Dosage forms	Capsule, extended release, Tablet, Suppository	Injectable
Drug class	Phenothiazine	Phenothiazine
Boxed warning	None	Boxed warning
Half-life	—	about 9 to 16 hours
Treats	Anxiety Disorders, Dementia, Nausea	Anaphylaxis, Allergic Conjunctivitis, Motion Sickness

compazine phenergan

Rating

70/100

New

Pharmacy pays

~$5.22 /30

~$1.53 /30

Type

Active ingredient

PROCHLORPERAZINE MALEATE

PROMETHAZINE HYDROCHLORIDE

Manufacturer

Glaxosmithkline

Pharmobedient

Dosage forms

Capsule, extended release, Tablet, Suppository

Injectable

Drug class

Phenothiazine

Boxed warning

None

Boxed warning

Half-life

—

about 9 to 16 hours

Treats

Anxiety Disorders, Dementia, Nausea

Anaphylaxis, Allergic Conjunctivitis, Motion Sickness

Frequently asked questions

Which is cheaper, Compazine or Phenergan?

Phenergan costs pharmacies less to acquire — about $1.53 vs $5.22 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Compazine and Phenergan?

Compazine contains Prochlorperazine Maleate, while Phenergan contains Promethazine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.