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COMPAZINE vs PERPHENAZINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 18, 2026·How we rate

Possible drug interaction. COMPAZINE and PERPHENAZINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

compazineperphenazine

Rating

70/100
68/100

Pharmacy pays

~$5.22 /30
~$5.68 /30

Type

RX
RX

Active ingredient

PROCHLORPERAZINE MALEATE
PERPHENAZINE

Manufacturer

Glaxosmithkline
Sandoz

Dosage forms

Capsule, extended release, Tablet, Suppository
Tablet

Drug class

Phenothiazine
Phenothiazine

Boxed warning

None
Boxed warning

Treats

Anxiety Disorders, Dementia, Nausea
Tourette Syndrome, Huntington Disease, Nausea

Frequently asked questions

Which is better-rated, Compazine or Perphenazine?

By our independent rating, Compazine scores higher — 3.5 vs 3.4 out of 5 for Perphenazine. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Compazine or Perphenazine?

Compazine costs pharmacies less to acquire — about $5.22 vs $5.68 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Compazine and Perphenazine?

Compazine contains Prochlorperazine Maleate, while Perphenazine contains Perphenazine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.