Skip to content
ppharmaranks
Menu

COMETRIQ vs MEKINIST

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. COMETRIQ and MEKINIST are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

Type

RX
RX

Active ingredient

CABOZANTINIB S-MALATE
TRAMETINIB DIMETHYL SULFOXIDE

Manufacturer

Dosage forms

Capsule, Kit
Powder, Tablet

Drug class

Kinase Inhibitor
Kinase Inhibitor

Boxed warning

None
None

Treats

Renal Cell Carcinoma
Non-Small-Cell Lung Carcinoma, Melanoma

Frequently asked questions

What is the difference between Cometriq and Mekinist?

Cometriq contains Cabozantinib S-Malate, while Mekinist contains Trametinib Dimethyl Sulfoxide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.