COMBIPRES vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. COMBIPRES and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COMBIPRES	MYSOLINE
Rating	72/100	74/100
Pharmacy pays	~$2.67 /30	~$2.89 /30
Type	RX	RX
Active ingredient	CHLORTHALIDONE AND CLONIDINE HYDROCHLORIDE	PRIMIDONE
Manufacturer	Boehringer Ingelheim	Valeant Pharm Intl
Dosage forms	Tablet	Tablet
Drug class	—	Anti-Epileptic Agent
Boxed warning	None	None
Half-life	about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)	—
Treats	—	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

combipres mysoline

Rating

72/100

74/100

Pharmacy pays

~$2.67 /30

~$2.89 /30

Type

Active ingredient

CHLORTHALIDONE AND CLONIDINE HYDROCHLORIDE

PRIMIDONE

Manufacturer

Boehringer Ingelheim

Valeant Pharm Intl

Dosage forms

Tablet

Drug class

—

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)

—

Treats

—

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is better-rated, Combipres or Mysoline?

By our independent rating, Mysoline scores higher — 3.7 vs 3.6 out of 5 for Combipres. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Combipres or Mysoline?

Combipres costs pharmacies less to acquire — about $2.67 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Combipres and Mysoline?

Combipres contains Chlorthalidone and Clonidine Hydrochloride, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.