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COLGATE TOTAL vs MYSOLINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 1, 2026·How we rate

Possible drug interaction. COLGATE TOTAL and MYSOLINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
74/100

Pharmacy pays

~$2.88 /30
~$2.89 /30

Type

RX
RX

Active ingredient

SODIUM FLUORIDE AND TRICLOSAN
PRIMIDONE

Dosage forms

Topical
Tablet

Drug class

—
Anti-Epileptic Agent

Boxed warning

None
None

Treats

—
Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

Frequently asked questions

Which is better-rated, Colgate Total or Mysoline?

By our independent rating, Mysoline scores higher — 3.7 vs 3.5 out of 5 for Colgate Total. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Colgate Total or Mysoline?

Colgate Total costs pharmacies less to acquire — about $2.88 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Colgate Total and Mysoline?

Colgate Total contains Sodium Fluoride and Triclosan, while Mysoline contains Primidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.