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COLGATE TOTAL vs CUPRIMINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 1, 2026·How we rate

Possible drug interaction. COLGATE TOTAL and CUPRIMINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
74/100

Pharmacy pays

~$2.88 /30
—

Type

RX
RX

Active ingredient

SODIUM FLUORIDE AND TRICLOSAN
PENICILLAMINE

Dosage forms

Topical
Capsule

Drug class

—
Antirheumatic Agent

Boxed warning

Treats

—
Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Frequently asked questions

Which is better-rated, Colgate Total or Cuprimine?

By our independent rating, Cuprimine scores higher — 3.7 vs 3.5 out of 5 for Colgate Total. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Colgate Total and Cuprimine?

Colgate Total contains Sodium Fluoride and Triclosan, while Cuprimine contains Penicillamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.