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COLESEVELAM HYDROCHLORIDE vs DIFICID

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. COLESEVELAM HYDROCHLORIDE and DIFICID are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

60/100
72/100

Pharmacy pays

~$8.28 /30
~$3903.18 /30

Type

RX
RX

Active ingredient

COLESEVELAM HYDROCHLORIDE
FIDAXOMICIN

Dosage forms

Powder, Tablet
Powder

Drug class

Bile Acid Sequestrant
Macrolide Antibacterial

Boxed warning

None
None

Treats

Coronary Artery Disease, Type 2 Diabetes Mellitus, Diarrhea
Pseudomembranous Enterocolitis

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Frequently asked questions

Which is better-rated, Colesevelam Hydrochloride or Dificid?

By our independent rating, Dificid scores higher — 3.6 vs 3.0 out of 5 for Colesevelam Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Colesevelam Hydrochloride or Dificid?

Colesevelam Hydrochloride costs pharmacies less to acquire — about $8.28 vs $3903.18 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Colesevelam Hydrochloride and Dificid?

Colesevelam Hydrochloride contains Colesevelam Hydrochloride, while Dificid contains Fidaxomicin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.