COLAZAL vs SERPASIL-ESIDRIX #1

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. COLAZAL and SERPASIL-ESIDRIX #1 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COLAZAL	SERPASIL-ESIDRIX #1
Rating	74/100	70/100
Pharmacy pays	~$11.02 /30	~$0.91 /30
Type	RX	RX
Active ingredient	BALSALAZIDE DISODIUM	HYDROCHLOROTHIAZIDE AND RESERPINE
Manufacturer	Valeant Pharm Intl	Novartis
Dosage forms	Capsule	Tablet
Drug class	Aminosalicylate	—
Boxed warning	None	None
Half-life	—	about 6 to 15 hours (the label reports a range, not a single number)
Treats	Ulcerative Colitis	—

colazal serpasil-esidrix #1

Rating

74/100

70/100

Pharmacy pays

~$11.02 /30

~$0.91 /30

Type

Active ingredient

BALSALAZIDE DISODIUM

HYDROCHLOROTHIAZIDE AND RESERPINE

Manufacturer

Valeant Pharm Intl

Novartis

Dosage forms

Capsule

Tablet

Drug class

Aminosalicylate

—

Boxed warning

None

Half-life

—

about 6 to 15 hours (the label reports a range, not a single number)

Treats

Ulcerative Colitis

—

Frequently asked questions

Which is better-rated, Colazal or Serpasil-Esidrix #1?

By our independent rating, Colazal scores higher — 3.7 vs 3.5 out of 5 for Serpasil-Esidrix #1. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Colazal or Serpasil-Esidrix #1?

Serpasil-Esidrix #1 costs pharmacies less to acquire — about $0.91 vs $11.02 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Colazal and Serpasil-Esidrix #1?

Colazal contains Balsalazide Disodium, while Serpasil-Esidrix #1 contains Hydrochlorothiazide and Reserpine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.