COLAZAL vs SEMPREX-D

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. COLAZAL and SEMPREX-D are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COLAZAL	SEMPREX-D
Rating	74/100	New
Pharmacy pays	~$11.02 /30	—
Type	RX	RX
Active ingredient	BALSALAZIDE DISODIUM	ACRIVASTINE AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Valeant Pharm Intl	Endo Operations
Dosage forms	Capsule	Capsule
Drug class	Aminosalicylate	—
Boxed warning	None	None
Half-life	—	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Ulcerative Colitis	—

colazal semprex-d

Rating

74/100

New

Pharmacy pays

~$11.02 /30

—

Type

Active ingredient

BALSALAZIDE DISODIUM

ACRIVASTINE AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Valeant Pharm Intl

Endo Operations

Dosage forms

Capsule

Drug class

Aminosalicylate

—

Boxed warning

None

Half-life

—

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Ulcerative Colitis

—

Frequently asked questions

What is the difference between Colazal and Semprex-D?

Colazal contains Balsalazide Disodium, while Semprex-D contains Acrivastine and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.