COLAZAL vs ORTHO-NOVUM 2-21

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. COLAZAL and ORTHO-NOVUM 2-21 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COLAZAL	ORTHO-NOVUM 2-21
Rating	74/100	New
Pharmacy pays	~$11.02 /30	—
Type	RX	RX
Active ingredient	BALSALAZIDE DISODIUM	MESTRANOL AND NORETHINDRONE
Manufacturer	Valeant Pharm Intl	Ortho Mcneil Pharm
Dosage forms	Capsule	Tablet
Drug class	Aminosalicylate	—
Boxed warning	None	None
Half-life	—	about 8 hours
Treats	Ulcerative Colitis	—

colazal ortho-novum 2-21

Rating

74/100

New

Pharmacy pays

~$11.02 /30

—

Type

Active ingredient

BALSALAZIDE DISODIUM

MESTRANOL AND NORETHINDRONE

Manufacturer

Valeant Pharm Intl

Ortho Mcneil Pharm

Dosage forms

Capsule

Tablet

Drug class

Aminosalicylate

—

Boxed warning

None

Half-life

—

about 8 hours

Treats

Ulcerative Colitis

—

Frequently asked questions

What is the difference between Colazal and Ortho-Novum 2-21?

Colazal contains Balsalazide Disodium, while Ortho-Novum 2-21 contains Mestranol and Norethindrone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.