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COLAZAL vs LYBALVI

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 9, 2026·How we rate

Possible drug interaction. COLAZAL and LYBALVI are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

74/100
72/100

Pharmacy pays

~$11.02 /30
~$4.13 /30

Type

RX
RX

Active ingredient

BALSALAZIDE DISODIUM
OLANZAPINE AND SAMIDORPHAN L-MALATE

Dosage forms

Capsule
Tablet

Drug class

Aminosalicylate
—

Boxed warning

Half-life

—
about 21 to 54 hours (mean around 30 hours)

Treats

Ulcerative Colitis
—

Frequently asked questions

Which is better-rated, Colazal or Lybalvi?

By our independent rating, Colazal scores higher — 3.7 vs 3.6 out of 5 for Lybalvi. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Colazal or Lybalvi?

Lybalvi costs pharmacies less to acquire — about $4.13 vs $11.02 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Colazal and Lybalvi?

Colazal contains Balsalazide Disodium, while Lybalvi contains Olanzapine and Samidorphan L-Malate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.