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COLAZAL vs KOMBIGLYZE XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 8, 2026·How we rate

Possible drug interaction. COLAZAL and KOMBIGLYZE XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

colazalkombiglyze xr

Rating

74/100
New

Pharmacy pays

~$11.02 /30
~$0.74 /30

Type

RX
RX

Active ingredient

BALSALAZIDE DISODIUM
METFORMIN HYDROCHLORIDE AND SAXAGLIPTIN HYDROCHLORIDE

Manufacturer

Valeant Pharm Intl
Astrazeneca Ab

Dosage forms

Capsule
Tablet, extended release

Drug class

Aminosalicylate
—

Boxed warning

None
None

Half-life

—
about 6.2 hours (plasma elimination half-life in adults with normal kidney function)

Treats

Ulcerative Colitis
—

Frequently asked questions

Which is cheaper, Colazal or Kombiglyze XR?

Kombiglyze XR costs pharmacies less to acquire — about $0.74 vs $11.02 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Colazal and Kombiglyze XR?

Colazal contains Balsalazide Disodium, while Kombiglyze XR contains Metformin Hydrochloride and Saxagliptin Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.