COLAZAL vs HYCOFENIX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. COLAZAL and HYCOFENIX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COLAZAL	HYCOFENIX
Rating	74/100	New
Pharmacy pays	~$11.02 /30	$0.07 /mL
Type	RX	RX
Active ingredient	BALSALAZIDE DISODIUM	GUAIFENESIN AND HYDROCODONE BITARTRATE AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Valeant Pharm Intl	Chartwell Rx
Dosage forms	Capsule	Solution
Drug class	Aminosalicylate	—
Boxed warning	None	None
Half-life	—	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)
Treats	Ulcerative Colitis	—

colazal hycofenix

Rating

74/100

New

Pharmacy pays

~$11.02 /30

$0.07 /mL

Type

Active ingredient

BALSALAZIDE DISODIUM

GUAIFENESIN AND HYDROCODONE BITARTRATE AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Valeant Pharm Intl

Chartwell Rx

Dosage forms

Capsule

Solution

Drug class

Aminosalicylate

—

Boxed warning

None

Half-life

—

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

Treats

Ulcerative Colitis

—

Frequently asked questions

What is the difference between Colazal and Hycofenix?

Colazal contains Balsalazide Disodium, while Hycofenix contains Guaifenesin and Hydrocodone Bitartrate and Pseudoephedrine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.