COLAZAL vs COMBIPRES

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. COLAZAL and COMBIPRES are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	COLAZAL	COMBIPRES
Rating	74/100	72/100
Pharmacy pays	~$11.02 /30	~$2.67 /30
Type	RX	RX
Active ingredient	BALSALAZIDE DISODIUM	CHLORTHALIDONE AND CLONIDINE HYDROCHLORIDE
Manufacturer	Valeant Pharm Intl	Boehringer Ingelheim
Dosage forms	Capsule	Tablet
Drug class	Aminosalicylate	—
Boxed warning	None	None
Half-life	—	about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)
Treats	Ulcerative Colitis	—

colazal combipres

Rating

74/100

72/100

Pharmacy pays

~$11.02 /30

~$2.67 /30

Type

Active ingredient

BALSALAZIDE DISODIUM

CHLORTHALIDONE AND CLONIDINE HYDROCHLORIDE

Manufacturer

Valeant Pharm Intl

Boehringer Ingelheim

Dosage forms

Capsule

Tablet

Drug class

Aminosalicylate

—

Boxed warning

None

Half-life

—

about 40 hours on average (the label reports a mean half-life of 40 hours after a 50–200 mg dose, and an elimination half-life of 53 hours after 50 mg and 60 hours after 100 mg)

Treats

Ulcerative Colitis

—

Frequently asked questions

Which is better-rated, Colazal or Combipres?

By our independent rating, Colazal scores higher — 3.7 vs 3.6 out of 5 for Combipres. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Colazal or Combipres?

Combipres costs pharmacies less to acquire — about $2.67 vs $11.02 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Colazal and Combipres?

Colazal contains Balsalazide Disodium, while Combipres contains Chlorthalidone and Clonidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.