CODIMAL-L.A. 12 vs CUPRIMINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. CODIMAL-L.A. 12 and CUPRIMINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CODIMAL-L.A. 12	CUPRIMINE
Rating	New	74/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	CHLORPHENIRAMINE MALEATE AND PSEUDOEPHEDRINE HYDROCHLORIDE	PENICILLAMINE
Manufacturer	Schwarz Pharma	Valeant Pharm Intl
Dosage forms	Capsule, extended release	Capsule
Drug class	—	Antirheumatic Agent
Boxed warning	None	Boxed warning
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	—
Treats	—	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

codimal-l.a. 12 cuprimine

Rating

New

74/100

Pharmacy pays

—

Type

Active ingredient

CHLORPHENIRAMINE MALEATE AND PSEUDOEPHEDRINE HYDROCHLORIDE

PENICILLAMINE

Manufacturer

Schwarz Pharma

Valeant Pharm Intl

Dosage forms

Capsule, extended release

Capsule

Drug class

—

Antirheumatic Agent

Boxed warning

None

Boxed warning

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

—

Treats

—

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Frequently asked questions

What is the difference between Codimal-L.A. 12 and Cuprimine?

Codimal-L.A. 12 contains Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride, while Cuprimine contains Penicillamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.