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CODEINE SULFATE vs ULTRAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. CODEINE SULFATE and ULTRAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
70/100

Pharmacy pays

~$20.44 /30
~$0.72 /30

Type

RX
RX

Active ingredient

CODEINE SULFATE
TRAMADOL HYDROCHLORIDE

Dosage forms

Tablet
Tablet

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Cough, Pain
Pain

Frequently asked questions

Which is better-rated, Codeine Sulfate or Ultram?

By our independent rating, Codeine Sulfate scores higher — 3.6 vs 3.5 out of 5 for Ultram. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Codeine Sulfate or Ultram?

Ultram costs pharmacies less to acquire — about $0.72 vs $20.44 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Codeine Sulfate and Ultram?

Codeine Sulfate contains Codeine Sulfate, while Ultram contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.