CODEINE SULFATE vs ROXICODONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. CODEINE SULFATE and ROXICODONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CODEINE SULFATE	ROXICODONE
Rating	72/100	70/100
Pharmacy pays	~$20.55 /30	$0.08 /mL
Type	RX	RX
Active ingredient	CODEINE SULFATE	OXYCODONE HYDROCHLORIDE
Manufacturer	Hikma	Roxane
Dosage forms	Tablet	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 3.5 to 4 hours
Treats	Cough, Pain	Postoperative Pain

codeine sulfate roxicodone

Rating

72/100

70/100

Pharmacy pays

~$20.55 /30

$0.08 /mL

Type

Active ingredient

CODEINE SULFATE

OXYCODONE HYDROCHLORIDE

Manufacturer

Hikma

Roxane

Dosage forms

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 3.5 to 4 hours

Treats

Cough, Pain

Postoperative Pain

Frequently asked questions

Which is better-rated, Codeine Sulfate or Roxicodone?

By our independent rating, Codeine Sulfate scores higher — 3.6 vs 3.5 out of 5 for Roxicodone. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Codeine Sulfate and Roxicodone?

Codeine Sulfate contains Codeine Sulfate, while Roxicodone contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.