CODEINE SULFATE vs NUCYNTA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 14, 2026·How we rate

Possible drug interaction. CODEINE SULFATE and NUCYNTA ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CODEINE SULFATE	NUCYNTA ER
Rating	72/100	New
Pharmacy pays	~$20.44 /30	~$342.56 /30
Type	RX	RX
Active ingredient	CODEINE SULFATE	TAPENTADOL HYDROCHLORIDE
Manufacturer	Hikma	Collegium Pharm Inc
Dosage forms	Tablet	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	—	about 5 hours (terminal half-life, on average, after oral administration)
Treats	Cough, Pain	Pain

codeine sulfate nucynta er

Rating

72/100

New

Pharmacy pays

~$20.44 /30

~$342.56 /30

Type

Active ingredient

CODEINE SULFATE

TAPENTADOL HYDROCHLORIDE

Manufacturer

Hikma

Collegium Pharm Inc

Dosage forms

Tablet

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

—

about 5 hours (terminal half-life, on average, after oral administration)

Treats

Cough, Pain

Pain

Frequently asked questions

Which is cheaper, Codeine Sulfate or Nucynta ER?

Codeine Sulfate costs pharmacies less to acquire — about $20.44 vs $342.56 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Codeine Sulfate and Nucynta ER?

Codeine Sulfate contains Codeine Sulfate, while Nucynta ER contains Tapentadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.