CODEINE SULFATE vs METHADONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. CODEINE SULFATE and METHADONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CODEINE SULFATE	METHADONE HYDROCHLORIDE
Rating	72/100	72/100
Pharmacy pays	~$20.44 /30	$0.18 /mL
Type	RX	RX
Active ingredient	CODEINE SULFATE	METHADONE HYDROCHLORIDE
Manufacturer	Hikma	Hikma
Dosage forms	Tablet	Injectable, Solution, Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	Boxed warning
Half-life	—	about 8 to 59 hours (terminal/elimination half-life; a very wide range)
Treats	Cough, Pain	Opioid-Related Disorders, Intractable Pain

codeine sulfate methadone hydrochloride

Rating

72/100

Pharmacy pays

~$20.44 /30

$0.18 /mL

Type

Active ingredient

CODEINE SULFATE

METHADONE HYDROCHLORIDE

Manufacturer

Hikma

Dosage forms

Tablet

Injectable, Solution, Tablet

Drug class

Opioid Agonist

Boxed warning

None

Boxed warning

Half-life

—

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Cough, Pain

Opioid-Related Disorders, Intractable Pain

Frequently asked questions

Which is better-rated, Codeine Sulfate or Methadone Hydrochloride?

Codeine Sulfate and Methadone Hydrochloride are tied at 3.6 out of 5 by our independent rating.

What is the difference between Codeine Sulfate and Methadone Hydrochloride?

Codeine Sulfate contains Codeine Sulfate, while Methadone Hydrochloride contains Methadone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.