CODEINE SULFATE vs EXALGO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. CODEINE SULFATE and EXALGO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CODEINE SULFATE	EXALGO
Rating	72/100	70/100
Pharmacy pays	~$20.44 /30	$0.57 /mL
Type	RX	RX
Active ingredient	CODEINE SULFATE	HYDROMORPHONE HYDROCHLORIDE
Manufacturer	Hikma	Specgx LLC
Dosage forms	Tablet	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
Treats	Cough, Pain	Cough, Postoperative Pain

codeine sulfate exalgo

Rating

72/100

70/100

Pharmacy pays

~$20.44 /30

$0.57 /mL

Type

Active ingredient

CODEINE SULFATE

HYDROMORPHONE HYDROCHLORIDE

Manufacturer

Hikma

Specgx LLC

Dosage forms

Tablet

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Cough, Pain

Cough, Postoperative Pain

Frequently asked questions

Which is better-rated, Codeine Sulfate or Exalgo?

By our independent rating, Codeine Sulfate scores higher — 3.6 vs 3.5 out of 5 for Exalgo. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Codeine Sulfate and Exalgo?

Codeine Sulfate contains Codeine Sulfate, while Exalgo contains Hydromorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.