CODEINE SULFATE vs DURAGESIC-50

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. CODEINE SULFATE and DURAGESIC-50 are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CODEINE SULFATE	DURAGESIC-50
Rating	72/100	70/100
Pharmacy pays	~$20.44 /30	$9.51 /mL
Type	RX	RX
Active ingredient	CODEINE SULFATE	FENTANYL
Manufacturer	Hikma	Janssen Pharms
Dosage forms	Tablet	Film, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Treats	Cough, Pain	Pain

codeine sulfate duragesic-50

Rating

72/100

70/100

Pharmacy pays

~$20.44 /30

$9.51 /mL

Type

Active ingredient

CODEINE SULFATE

FENTANYL

Manufacturer

Hikma

Janssen Pharms

Dosage forms

Tablet

Film, extended release

Drug class

Opioid Agonist

Boxed warning

None

Treats

Cough, Pain

Pain

Frequently asked questions

Which is better-rated, Codeine Sulfate or Duragesic-50?

By our independent rating, Codeine Sulfate scores higher — 3.6 vs 3.5 out of 5 for Duragesic-50. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Codeine Sulfate and Duragesic-50?

Codeine Sulfate contains Codeine Sulfate, while Duragesic-50 contains Fentanyl — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.