CLOZARIL vs REXULTI

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. CLOZARIL and REXULTI are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CLOZARIL	REXULTI
Rating	New	New
Pharmacy pays	~$30.62 /30	—
Type	RX	RX
Active ingredient	CLOZAPINE	BREXPIPRAZOLE
Manufacturer	Heritage Life	Otsuka
Dosage forms	Tablet	Tablet, Kit
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	about 12 hours at steady state (the label gives a mean elimination half-life of 12 hours, range 4 to 66 hours, after 100 mg twice daily); after a single 75 mg dose the mean is 8 hours (range 4 to 12 hours)	—
Treats	Bipolar Disorder, Psychotic Disorders, Schizophrenia	Major Depressive Disorder, Schizophrenia

clozaril rexulti

Rating

New

Pharmacy pays

~$30.62 /30

—

Type

Active ingredient

CLOZAPINE

BREXPIPRAZOLE

Manufacturer

Heritage Life

Otsuka

Dosage forms

Tablet

Tablet, Kit

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

about 12 hours at steady state (the label gives a mean elimination half-life of 12 hours, range 4 to 66 hours, after 100 mg twice daily); after a single 75 mg dose the mean is 8 hours (range 4 to 12 hours)

—

Treats

Bipolar Disorder, Psychotic Disorders, Schizophrenia

Major Depressive Disorder, Schizophrenia

Frequently asked questions

What is the difference between Clozaril and Rexulti?

Clozaril contains Clozapine, while Rexulti contains Brexpiprazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.