CLOZARIL vs LURASIDONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. CLOZARIL and LURASIDONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CLOZARIL	LURASIDONE HYDROCHLORIDE
Rating	New	New
Pharmacy pays	~$30.62 /30	~$9.42 /30
Type	RX	RX
Active ingredient	CLOZAPINE	LURASIDONE HYDROCHLORIDE
Manufacturer	Heritage Life	Chartwell Rx
Dosage forms	Tablet	Tablet
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	about 12 hours at steady state (the label gives a mean elimination half-life of 12 hours, range 4 to 66 hours, after 100 mg twice daily); after a single 75 mg dose the mean is 8 hours (range 4 to 12 hours)	about 18 hours (mean, %CV 7), measured after a 40 mg oral dose in adults
Treats	Bipolar Disorder, Psychotic Disorders, Schizophrenia	Bipolar Disorder, Major Depressive Disorder, Schizophrenia

clozaril lurasidone hydrochloride

Rating

New

Pharmacy pays

~$30.62 /30

~$9.42 /30

Type

Active ingredient

CLOZAPINE

LURASIDONE HYDROCHLORIDE

Manufacturer

Heritage Life

Chartwell Rx

Dosage forms

Tablet

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

about 12 hours at steady state (the label gives a mean elimination half-life of 12 hours, range 4 to 66 hours, after 100 mg twice daily); after a single 75 mg dose the mean is 8 hours (range 4 to 12 hours)

about 18 hours (mean, %CV 7), measured after a 40 mg oral dose in adults

Treats

Bipolar Disorder, Psychotic Disorders, Schizophrenia

Bipolar Disorder, Major Depressive Disorder, Schizophrenia

Frequently asked questions

Which is cheaper, Clozaril or Lurasidone Hydrochloride?

Lurasidone Hydrochloride costs pharmacies less to acquire — about $9.42 vs $30.62 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Clozaril and Lurasidone Hydrochloride?

Clozaril contains Clozapine, while Lurasidone Hydrochloride contains Lurasidone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.