CLOZAPINE vs RISPERDAL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. CLOZAPINE and RISPERDAL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CLOZAPINE	RISPERDAL
Rating	70/100	70/100
Pharmacy pays	~$30.62 /30	~$2.07 /30
Type	RX	RX
Active ingredient	CLOZAPINE	RISPERIDONE
Manufacturer	Par Pharm	Janssen Pharms
Dosage forms	Tablet, Tablet, orally disintegrating	Solution, Tablet
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	None	Boxed warning
Half-life	about 12 hours at steady state (the label gives a mean elimination half-life of 12 hours, range 4 to 66 hours, after 100 mg twice daily); after a single 75 mg dose the mean is 8 hours (range 4 to 12 hours)	about 3 hours in extensive CYP2D6 metabolizers (about 20 hours in poor metabolizers)
Treats	Bipolar Disorder, Psychotic Disorders, Schizophrenia	Autistic Disorder, Bipolar Disorder, Dementia

clozapine risperdal

Rating

70/100

Pharmacy pays

~$30.62 /30

~$2.07 /30

Type

Active ingredient

CLOZAPINE

RISPERIDONE

Manufacturer

Par Pharm

Janssen Pharms

Dosage forms

Tablet, Tablet, orally disintegrating

Solution, Tablet

Drug class

Atypical Antipsychotic

Boxed warning

None

Boxed warning

Half-life

about 12 hours at steady state (the label gives a mean elimination half-life of 12 hours, range 4 to 66 hours, after 100 mg twice daily); after a single 75 mg dose the mean is 8 hours (range 4 to 12 hours)

about 3 hours in extensive CYP2D6 metabolizers (about 20 hours in poor metabolizers)

Treats

Bipolar Disorder, Psychotic Disorders, Schizophrenia

Autistic Disorder, Bipolar Disorder, Dementia

Frequently asked questions

Which is better-rated, Clozapine or Risperdal?

Clozapine and Risperdal are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Clozapine or Risperdal?

Risperdal costs pharmacies less to acquire — about $2.07 vs $30.62 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Clozapine and Risperdal?

Clozapine contains Clozapine, while Risperdal contains Risperidone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.