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CLONIDINE HYDROCHLORIDE vs ZANAFLEX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. CLONIDINE HYDROCHLORIDE and ZANAFLEX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

clonidine hydrochloridezanaflex

Rating

72/100
New

Pharmacy pays

~$1.05 /30
~$1.00 /30

Type

RX
RX

Active ingredient

CLONIDINE HYDROCHLORIDE
TIZANIDINE HYDROCHLORIDE

Manufacturer

Actavis Elizabeth
Legacy Pharma

Dosage forms

Injectable, Tablet, Tablet, extended release
Capsule, Tablet

Drug class

Central Alpha-2 Adrenergic Agonist
Central Alpha-2 Adrenergic Agonist

Boxed warning

None
None

Half-life

about 12 to 16 hours
about 2.5 hours

Treats

Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea
Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Frequently asked questions

Which is cheaper, Clonidine Hydrochloride or Zanaflex?

Zanaflex costs pharmacies less to acquire — about $1.00 vs $1.05 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Clonidine Hydrochloride and Zanaflex?

Clonidine Hydrochloride contains Clonidine Hydrochloride, while Zanaflex contains Tizanidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.