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CLOCORTOLONE PIVALATE vs HYDROCORTISONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. CLOCORTOLONE PIVALATE and HYDROCORTISONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
New

Pharmacy pays

$5.21 /g
$0.15 /g

Type

RX
RX

Active ingredient

CLOCORTOLONE PIVALATE
HYDROCORTISONE

Manufacturer

Dosage forms

Topical
Spray/Inhaler, Topical, Enema, Solution, Suspension, Tablet

Drug class

Corticosteroid
Corticosteroid

Boxed warning

None
None

Half-life

about 1.5 hours

Treats

Facial Dermatoses, Foot Dermatoses, Hand Dermatoses
Adrenal Insufficiency, Congenital Adrenal Hyperplasia, Ulcerative Colitis

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Frequently asked questions

Which is cheaper, Clocortolone Pivalate or Hydrocortisone?

Hydrocortisone costs pharmacies less to acquire — about $0.15 vs $5.21 per gm, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Clocortolone Pivalate and Hydrocortisone?

Clocortolone Pivalate contains Clocortolone Pivalate, while Hydrocortisone contains Hydrocortisone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.