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CHILDREN'S ZYRTEC HIVES RELIEF vs XYZAL ALLERGY 24HR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Rating

70/100
New

Pharmacy pays

$0.06 /mL
$0.06 /mL

Type

RX
OTC

Active ingredient

CETIRIZINE HYDROCHLORIDE
LEVOCETIRIZINE DIHYDROCHLORIDE

Dosage forms

Tablet, chewable
Tablet

Drug class

Histamine-1 Receptor Antagonist
Histamine-1 Receptor Antagonist

Boxed warning

None
None

Half-life

about 8.3 hours (mean in healthy adults)

Treats

Perennial Allergic Rhinitis, Urticaria
Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis, Urticaria

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Frequently asked questions

Which is cheaper, Children's Zyrtec Hives Relief or Xyzal Allergy 24hr?

Xyzal Allergy 24hr costs pharmacies less to acquire — about $0.06 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Children's Zyrtec Hives Relief and Xyzal Allergy 24hr?

Children's Zyrtec Hives Relief contains Cetirizine Hydrochloride, while Xyzal Allergy 24hr contains Levocetirizine Dihydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.