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CHILDREN'S ZYRTEC HIVES RELIEF vs XYZAL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. CHILDREN'S ZYRTEC HIVES RELIEF and XYZAL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
New

Pharmacy pays

$0.06 /mL
$0.06 /mL

Type

RX
RX

Active ingredient

CETIRIZINE HYDROCHLORIDE
LEVOCETIRIZINE DIHYDROCHLORIDE

Dosage forms

Tablet, chewable
Solution, Tablet

Drug class

Histamine-1 Receptor Antagonist
Histamine-1 Receptor Antagonist

Boxed warning

None
None

Half-life

about 8.3 hours (mean in healthy adults)

Treats

Perennial Allergic Rhinitis, Urticaria
Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis, Urticaria

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Frequently asked questions

Which is cheaper, Children's Zyrtec Hives Relief or Xyzal?

Xyzal costs pharmacies less to acquire — about $0.06 vs $0.06 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Children's Zyrtec Hives Relief and Xyzal?

Children's Zyrtec Hives Relief contains Cetirizine Hydrochloride, while Xyzal contains Levocetirizine Dihydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.