CHILDREN'S ALLEGRA HIVES vs CHILDREN'S ZYRTEC HIVES RELIEF

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. CHILDREN'S ALLEGRA HIVES and CHILDREN'S ZYRTEC HIVES RELIEF are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CHILDREN'S ALLEGRA HIVES	CHILDREN'S ZYRTEC HIVES RELIEF
Rating	New	70/100
Pharmacy pays	~$7.33 /30	$0.06 /mL
Type	RX	RX
Active ingredient	FEXOFENADINE HYDROCHLORIDE	CETIRIZINE HYDROCHLORIDE
Manufacturer	Chattem Sanofi	Kenvue Brands
Dosage forms	Tablet, orally disintegrating	Tablet, chewable
Drug class	Histamine-1 Receptor Antagonist	Histamine-1 Receptor Antagonist
Boxed warning	None	None
Half-life	about 14 hours (label: mean elimination half-life 14.4 hours)	about 8.3 hours (mean in healthy adults)
Treats	Perennial Allergic Rhinitis, Urticaria	Perennial Allergic Rhinitis, Urticaria

children's allegra hives children's zyrtec hives relief

Rating

New

70/100

Pharmacy pays

~$7.33 /30

$0.06 /mL

Type

Active ingredient

FEXOFENADINE HYDROCHLORIDE

CETIRIZINE HYDROCHLORIDE

Manufacturer

Chattem Sanofi

Kenvue Brands

Dosage forms

Tablet, orally disintegrating

Tablet, chewable

Drug class

Histamine-1 Receptor Antagonist

Boxed warning

None

Half-life

about 14 hours (label: mean elimination half-life 14.4 hours)

about 8.3 hours (mean in healthy adults)

Treats

Perennial Allergic Rhinitis, Urticaria

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Frequently asked questions

What is the difference between Children's Allegra Hives and Children's Zyrtec Hives Relief?

Children's Allegra Hives contains Fexofenadine Hydrochloride, while Children's Zyrtec Hives Relief contains Cetirizine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.