CHILDREN'S ADVIL vs PENNSAID

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. CHILDREN'S ADVIL and PENNSAID are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CHILDREN'S ADVIL	PENNSAID
Rating	72/100	New
Pharmacy pays	$0.04 /mL	$0.36 /mL
Type	RX	RX
Active ingredient	IBUPROFEN	DICLOFENAC SODIUM
Manufacturer	Haleon US Holdings	Horizon
Dosage forms	Suspension, Tablet, chewable	Solution
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	about 1.8 to 2.0 hours	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Bursitis	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

children's advil pennsaid

Rating

72/100

New

Pharmacy pays

$0.04 /mL

$0.36 /mL

Type

Active ingredient

IBUPROFEN

DICLOFENAC SODIUM

Manufacturer

Haleon US Holdings

Horizon

Dosage forms

Suspension, Tablet, chewable

Solution

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 1.8 to 2.0 hours

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

Which is cheaper, Children's Advil or Pennsaid?

Children's Advil costs pharmacies less to acquire — about $0.04 vs $0.36 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Children's Advil and Pennsaid?

Children's Advil contains Ibuprofen, while Pennsaid contains Diclofenac Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.