CETIRIZINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDE vs ZYRTEC-D 12 HOUR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	CETIRIZINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDE	ZYRTEC-D 12 HOUR
Rating	New	70/100
Pharmacy pays	$0.06 /mL	$0.06 /mL
Type	OTC	OTC
Active ingredient	CETIRIZINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDE	CETIRIZINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDE
Manufacturer	Pld Acquisitions LLC	Kenvue Brands
Dosage forms	Tablet, extended release	Tablet, extended release
Drug class	—	—
Boxed warning	None	None
Half-life	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)	roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

cetirizine hydrochloride and pseudoephedrine hydrochloride zyrtec-d 12 hour

Rating

New

70/100

Pharmacy pays

$0.06 /mL

Type

OTC

Active ingredient

CETIRIZINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDE

Manufacturer

Pld Acquisitions LLC

Kenvue Brands

Dosage forms

Tablet, extended release

Drug class

—

Boxed warning

None

Half-life

roughly 3 to 16 hours — the label does not give one number, because the elimination half-life depends on urine pH: about 3 to 6 hours when urine pH is 5 (acidic), and about 9 to 16 hours when urine pH is 8 (alkaline)

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Frequently asked questions

Which is cheaper, Cetirizine Hydrochloride and Pseudoephedrine Hydrochloride or Zyrtec-D 12 Hour?

Pharmacies pay about the same to acquire either one — roughly $0.06 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Cetirizine Hydrochloride and Pseudoephedrine Hydrochloride and Zyrtec-D 12 Hour?

Both Cetirizine Hydrochloride and Pseudoephedrine Hydrochloride and Zyrtec-D 12 Hour share the active ingredient Cetirizine Hydrochloride and Pseudoephedrine Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.