CELEXA vs ZOLOFT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. CELEXA and ZOLOFT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CELEXA	ZOLOFT
Rating	70/100	70/100
Pharmacy pays	—	~$1.09 /30
Type	RX	RX
Active ingredient	CITALOPRAM HYDROBROMIDE	SERTRALINE HYDROCHLORIDE
Manufacturer	Forest Labs	Viatris
Dosage forms	Tablet	Solution, Tablet
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	None	Boxed warning
Half-life	about 35 hours	about 26 hours
Treats	Alcoholism, Dementia, Depressive Disorder	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

celexa zoloft

Rating

70/100

Pharmacy pays

—

~$1.09 /30

Type

Active ingredient

CITALOPRAM HYDROBROMIDE

SERTRALINE HYDROCHLORIDE

Manufacturer

Forest Labs

Viatris

Dosage forms

Tablet

Solution, Tablet

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Boxed warning

Half-life

about 35 hours

about 26 hours

Treats

Alcoholism, Dementia, Depressive Disorder

Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

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Frequently asked questions

Which is better-rated, Celexa or Zoloft?

Celexa and Zoloft are tied at 3.5 out of 5 by our independent rating.

What is the difference between Celexa and Zoloft?

Celexa contains Citalopram Hydrobromide, while Zoloft contains Sertraline Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.