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CEFIXIME vs NITROFURANTOIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. CEFIXIME and NITROFURANTOIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
70/100

Pharmacy pays

$10.03 /mL
$2.11 /mL

Type

RX
RX

Active ingredient

CEFIXIME
NITROFURANTOIN

Manufacturer

Dosage forms

Capsule, Powder, Tablet
Capsule, Suspension

Drug class

Cephalosporin Antibacterial
Nitrofuran Antibacterial

Boxed warning

None
None

Half-life

about 20 minutes (roughly 0.3 hours) for the parent drug in adults with normal kidney function

Treats

Bronchitis, Escherichia Coli Infections, Gonorrhea
Escherichia Coli Infections, Klebsiella Infections, Staphylococcal Infections

Get cefiximehigher-rated option

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Frequently asked questions

Which is better-rated, Cefixime or Nitrofurantoin?

By our independent rating, Cefixime scores higher — 3.6 vs 3.5 out of 5 for Nitrofurantoin. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Cefixime or Nitrofurantoin?

Nitrofurantoin costs pharmacies less to acquire — about $2.11 vs $10.03 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Cefixime and Nitrofurantoin?

Cefixime contains Cefixime, while Nitrofurantoin contains Nitrofurantoin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.