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CATAPRES-TTS-3 vs GUANFACINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. CATAPRES-TTS-3 and GUANFACINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
72/100

Pharmacy pays

~$1.05 /30
~$5.26 /30

Type

RX
RX

Active ingredient

CLONIDINE
GUANFACINE HYDROCHLORIDE

Dosage forms

Patch
Tablet

Drug class

Central Alpha-2 Adrenergic Agonist
Central Alpha-2 Adrenergic Agonist

Boxed warning

None
None

Half-life

about 12 to 16 hours

Treats

Attention Deficit Disorder with Hyperactivity, Diarrhea, Dysmenorrhea
Attention Deficit Disorder with Hyperactivity, Hypertension

Get guanfacine hydrochloridehigher-rated option

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Frequently asked questions

Which is cheaper, Catapres-Tts-3 or Guanfacine Hydrochloride?

Catapres-Tts-3 costs pharmacies less to acquire — about $1.05 vs $5.26 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Catapres-Tts-3 and Guanfacine Hydrochloride?

Catapres-Tts-3 contains Clonidine, while Guanfacine Hydrochloride contains Guanfacine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.