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CARDENE vs PROCARDIA XL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. CARDENE and PROCARDIA XL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

70/100
64/100

Pharmacy pays

~$41.18 /30
~$5.18 /30

Type

RX
RX

Active ingredient

NICARDIPINE HYDROCHLORIDE
NIFEDIPINE

Manufacturer

Dosage forms

Injectable
Tablet, extended release

Drug class

Dihydropyridine Calcium Channel Blocker
Dihydropyridine Calcium Channel Blocker

Boxed warning

None
None

Half-life

about 2 hours from an immediate-release capsule; about 7 hours as measured from the once-daily extended-release tablet

Treats

Variant Angina Pectoris, Hypertension, Stable Angina
Variant Angina Pectoris, Hypertension, Stable Angina

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Frequently asked questions

Which is better-rated, Cardene or Procardia XL?

By our independent rating, Cardene scores higher — 3.5 vs 3.2 out of 5 for Procardia XL. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Cardene or Procardia XL?

Procardia XL costs pharmacies less to acquire — about $5.18 vs $41.18 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Cardene and Procardia XL?

Cardene contains Nicardipine Hydrochloride, while Procardia XL contains Nifedipine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.