CALDOLOR vs CAMBIA

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 30, 2026·How we rate

Possible drug interaction. CALDOLOR and CAMBIA are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CALDOLOR	CAMBIA
Rating	New	New
Pharmacy pays	$0.04 /mL	$0.36 /mL
Type	RX	RX
Active ingredient	IBUPROFEN	DICLOFENAC POTASSIUM
Manufacturer	Cumberland	Assertio Speclty
Dosage forms	Injectable	Powder
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	Boxed warning	Boxed warning
Half-life	about 1.8 to 2.0 hours	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Juvenile Arthritis, Rheumatoid Arthritis, Bursitis	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

caldolor cambia

Rating

New

Pharmacy pays

$0.04 /mL

$0.36 /mL

Type

Active ingredient

IBUPROFEN

DICLOFENAC POTASSIUM

Manufacturer

Cumberland

Assertio Speclty

Dosage forms

Injectable

Powder

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

Half-life

about 1.8 to 2.0 hours

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

Which is cheaper, Caldolor or Cambia?

Caldolor costs pharmacies less to acquire — about $0.04 vs $0.36 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Caldolor and Cambia?

Caldolor contains Ibuprofen, while Cambia contains Diclofenac Potassium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.