CAFFEINE CITRATE vs DEXEDRINE SPANSULE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. CAFFEINE CITRATE and DEXEDRINE SPANSULE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CAFFEINE CITRATE	DEXEDRINE SPANSULE
Rating	68/100	70/100
Pharmacy pays	~$2.58 /30	~$29.94 /30
Type	RX	RX
Active ingredient	CAFFEINE CITRATE	DEXTROAMPHETAMINE SULFATE
Manufacturer	Fresenius Kabi USA	Impax
Dosage forms	Injectable, Solution	Capsule, extended release
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	None	Boxed warning
Treats	Apnea, Fatigue	Attention Deficit Disorder with Hyperactivity, Narcolepsy

caffeine citrate dexedrine spansule

Rating

68/100

70/100

Pharmacy pays

~$2.58 /30

~$29.94 /30

Type

Active ingredient

CAFFEINE CITRATE

DEXTROAMPHETAMINE SULFATE

Manufacturer

Fresenius Kabi USA

Impax

Dosage forms

Injectable, Solution

Capsule, extended release

Drug class

Central Nervous System Stimulant

Boxed warning

None

Boxed warning

Treats

Apnea, Fatigue

Attention Deficit Disorder with Hyperactivity, Narcolepsy

Frequently asked questions

Which is better-rated, Caffeine Citrate or Dexedrine Spansule?

By our independent rating, Dexedrine Spansule scores higher — 3.5 vs 3.4 out of 5 for Caffeine Citrate. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Caffeine Citrate or Dexedrine Spansule?

Caffeine Citrate costs pharmacies less to acquire — about $2.58 vs $29.94 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Caffeine Citrate and Dexedrine Spansule?

Caffeine Citrate contains Caffeine Citrate, while Dexedrine Spansule contains Dextroamphetamine Sulfate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.