CAFFEINE CITRATE vs COTEMPLA XR-ODT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. CAFFEINE CITRATE and COTEMPLA XR-ODT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	CAFFEINE CITRATE	COTEMPLA XR-ODT
Rating	68/100	New
Pharmacy pays	~$2.58 /30	~$18.94 /30
Type	RX	RX
Active ingredient	CAFFEINE CITRATE	METHYLPHENIDATE
Manufacturer	Fresenius Kabi USA	Neos Theraps Inc
Dosage forms	Injectable, Solution	Tablet, orally disintegrating
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	None	Boxed warning
Half-life	—	about 2.7 hours
Treats	Apnea, Fatigue	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

caffeine citrate cotempla xr-odt

Rating

68/100

New

Pharmacy pays

~$2.58 /30

~$18.94 /30

Type

Active ingredient

CAFFEINE CITRATE

METHYLPHENIDATE

Manufacturer

Fresenius Kabi USA

Neos Theraps Inc

Dosage forms

Injectable, Solution

Tablet, orally disintegrating

Drug class

Central Nervous System Stimulant

Boxed warning

None

Boxed warning

Half-life

—

about 2.7 hours

Treats

Apnea, Fatigue

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is cheaper, Caffeine Citrate or Cotempla XR-ODT?

Caffeine Citrate costs pharmacies less to acquire — about $2.58 vs $18.94 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Caffeine Citrate and Cotempla XR-ODT?

Caffeine Citrate contains Caffeine Citrate, while Cotempla XR-ODT contains Methylphenidate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.