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CAFCIT vs COTEMPLA XR-ODT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. CAFCIT and COTEMPLA XR-ODT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

cafcitcotempla xr-odt

Rating

72/100
New

Pharmacy pays

~$2.58 /30
~$18.94 /30

Type

RX
RX

Active ingredient

CAFFEINE CITRATE
METHYLPHENIDATE

Manufacturer

Hikma
Neos Theraps Inc

Dosage forms

Injectable
Tablet, orally disintegrating

Drug class

Central Nervous System Stimulant
Central Nervous System Stimulant

Boxed warning

None
Boxed warning

Half-life

—
about 2.7 hours

Treats

Apnea, Fatigue
Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is cheaper, Cafcit or Cotempla XR-ODT?

Cafcit costs pharmacies less to acquire — about $2.58 vs $18.94 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Cafcit and Cotempla XR-ODT?

Cafcit contains Caffeine Citrate, while Cotempla XR-ODT contains Methylphenidate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.