BUSPIRONE HYDROCHLORIDE vs HYDROXYZINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. BUSPIRONE HYDROCHLORIDE and HYDROXYZINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BUSPIRONE HYDROCHLORIDE	HYDROXYZINE HYDROCHLORIDE
Rating	70/100	New
Pharmacy pays	~$1.27 /30	$0.04 /mL
Type	RX	RX
Active ingredient	BUSPIRONE HYDROCHLORIDE	HYDROXYZINE HYDROCHLORIDE
Manufacturer	Impax	Pliva
Dosage forms	Tablet	Injectable, Solution, Syrup, Tablet
Drug class	—	Antihistamine
Boxed warning	None	None
Half-life	about 2 to 3 hours	about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)
Treats	Anxiety Disorders, Depressive Disorder, Intellectual Disability	Anxiety Disorders, Nausea, Pruritus

buspirone hydrochloride hydroxyzine hydrochloride

Rating

70/100

New

Pharmacy pays

~$1.27 /30

$0.04 /mL

Type

Active ingredient

BUSPIRONE HYDROCHLORIDE

HYDROXYZINE HYDROCHLORIDE

Manufacturer

Impax

Pliva

Dosage forms

Tablet

Injectable, Solution, Syrup, Tablet

Drug class

—

Antihistamine

Boxed warning

None

Half-life

about 2 to 3 hours

about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)

Treats

Anxiety Disorders, Depressive Disorder, Intellectual Disability

Anxiety Disorders, Nausea, Pruritus

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Frequently asked questions

What is the difference between Buspirone Hydrochloride and Hydroxyzine Hydrochloride?

Buspirone Hydrochloride contains Buspirone Hydrochloride, while Hydroxyzine Hydrochloride contains Hydroxyzine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.