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BUPIVACAINE HYDROCHLORIDE vs EXPAREL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. BUPIVACAINE HYDROCHLORIDE and EXPAREL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

bupivacaine hydrochlorideexparel

Rating

New
70/100

Pharmacy pays

$0.06 /mL
$0.06 /mL

Type

RX
RX

Active ingredient

BUPIVACAINE HYDROCHLORIDE
BUPIVACAINE

Manufacturer

Onesource Specialty
Pacira Pharms Inc

Dosage forms

Injectable
Injectable, Liposomal

Drug class

Amide Local Anesthetic
Amide Local Anesthetic

Boxed warning

Boxed warning
None

Treats

Postoperative Pain
Postoperative Pain

Frequently asked questions

Which is cheaper, Bupivacaine Hydrochloride or Exparel?

Pharmacies pay about the same to acquire either one — roughly $0.06 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Bupivacaine Hydrochloride and Exparel?

Bupivacaine Hydrochloride contains Bupivacaine Hydrochloride, while Exparel contains Bupivacaine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.