BRYNOVIN vs GLUCOPHAGE XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. BRYNOVIN and GLUCOPHAGE XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BRYNOVIN	GLUCOPHAGE XR
Rating	72/100	70/100
Pharmacy pays	~$110.51 /30	~$0.74 /30
Type	RX	RX
Active ingredient	SITAGLIPTIN HYDROCHLORIDE	METFORMIN HYDROCHLORIDE
Manufacturer	Azurity	Emd Serono
Dosage forms	Solution	Tablet, extended release
Drug class	Dipeptidyl Peptidase 4 Inhibitor	Biguanide
Boxed warning	None	None
Half-life	about 12.4 hours (apparent terminal half-life after a single 100 mg oral dose in healthy volunteers)	about 6.2 hours (plasma elimination half-life in adults with normal kidney function)
Treats	Type 2 Diabetes Mellitus	Type 2 Diabetes Mellitus

brynovin glucophage xr

Rating

72/100

70/100

Pharmacy pays

~$110.51 /30

~$0.74 /30

Type

Active ingredient

SITAGLIPTIN HYDROCHLORIDE

METFORMIN HYDROCHLORIDE

Manufacturer

Azurity

Emd Serono

Dosage forms

Solution

Tablet, extended release

Drug class

Dipeptidyl Peptidase 4 Inhibitor

Biguanide

Boxed warning

None

Half-life

about 12.4 hours (apparent terminal half-life after a single 100 mg oral dose in healthy volunteers)

about 6.2 hours (plasma elimination half-life in adults with normal kidney function)

Treats

Type 2 Diabetes Mellitus

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Frequently asked questions

Which is better-rated, Brynovin or Glucophage XR?

By our independent rating, Brynovin scores higher — 3.6 vs 3.5 out of 5 for Glucophage XR. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Brynovin or Glucophage XR?

Glucophage XR costs pharmacies less to acquire — about $0.74 vs $110.51 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Brynovin and Glucophage XR?

Brynovin contains Sitagliptin Hydrochloride, while Glucophage XR contains Metformin Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.