BRETYLOL vs MEXILETINE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. BRETYLOL and MEXILETINE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BRETYLOL	MEXILETINE HYDROCHLORIDE
Rating	60/100	70/100
Pharmacy pays	—	~$8.44 /30
Type	RX	RX
Active ingredient	BRETYLIUM TOSYLATE	MEXILETINE HYDROCHLORIDE
Manufacturer	Hospira	Macleods Pharms Ltd
Dosage forms	Injectable	Capsule
Drug class	—	Antiarrhythmic
Boxed warning	None	None
Treats	Ventricular Fibrillation, Ventricular Tachycardia	Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes

bretylol mexiletine hydrochloride

Rating

60/100

70/100

Pharmacy pays

—

~$8.44 /30

Type

Active ingredient

BRETYLIUM TOSYLATE

MEXILETINE HYDROCHLORIDE

Manufacturer

Hospira

Macleods Pharms Ltd

Dosage forms

Injectable

Capsule

Drug class

—

Antiarrhythmic

Boxed warning

None

Treats

Ventricular Fibrillation, Ventricular Tachycardia

Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes

Frequently asked questions

Which is better-rated, Bretylol or Mexiletine Hydrochloride?

By our independent rating, Mexiletine Hydrochloride scores higher — 3.5 vs 3.0 out of 5 for Bretylol. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Bretylol and Mexiletine Hydrochloride?

Bretylol contains Bretylium Tosylate, while Mexiletine Hydrochloride contains Mexiletine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.