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BREKIYA (AUTOINJECTOR) vs D.H.E. 45

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Rating

70/100
New

Pharmacy pays

$34.84 /mL
$34.84 /mL

Type

RX
RX

Active ingredient

DIHYDROERGOTAMINE MESYLATE
DIHYDROERGOTAMINE MESYLATE

Manufacturer

Dosage forms

Injectable
Injectable

Drug class

Ergotamine Derivative
Ergotamine Derivative

Boxed warning

Half-life

about 9 to 13 hours, depending on the form
about 9 to 13 hours, depending on the form

Treats

Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension
Cluster Headache, Postpartum Hemorrhage, Orthostatic Hypotension

Frequently asked questions

Which is cheaper, Brekiya (Autoinjector) or D.H.E. 45?

Pharmacies pay about the same to acquire either one — roughly $34.84 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Brekiya (Autoinjector) and D.H.E. 45?

Both Brekiya (Autoinjector) and D.H.E. 45 share the active ingredient Dihydroergotamine Mesylate.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.