BIPHETAMINE 12.5 vs CUPRIMINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. BIPHETAMINE 12.5 and CUPRIMINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BIPHETAMINE 12.5	CUPRIMINE
Rating	70/100	74/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	AMPHETAMINE RESIN COMPLEX AND DEXTROAMPHETAMINE RESIN COMPLEX	PENICILLAMINE
Manufacturer	Ucb Inc	Valeant Pharm Intl
Dosage forms	Capsule, extended release	Capsule
Drug class	—	Antirheumatic Agent
Boxed warning	None	Boxed warning
Half-life	about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults	—
Treats	—	Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

biphetamine 12.5 cuprimine

Rating

70/100

74/100

Pharmacy pays

—

Type

Active ingredient

AMPHETAMINE RESIN COMPLEX AND DEXTROAMPHETAMINE RESIN COMPLEX

PENICILLAMINE

Manufacturer

Ucb Inc

Valeant Pharm Intl

Dosage forms

Capsule, extended release

Capsule

Drug class

—

Antirheumatic Agent

Boxed warning

None

Boxed warning

Half-life

about 10 to 11 hours for d-amphetamine (range 9.8 to 11 hours) and about 12 to 14 hours for l-amphetamine (range 11.5 to 13.8 hours) in healthy adults

—

Treats

—

Rheumatoid Arthritis, Cystinuria, Hepatolenticular Degeneration

Frequently asked questions

Which is better-rated, Biphetamine 12.5 or Cuprimine?

By our independent rating, Cuprimine scores higher — 3.7 vs 3.5 out of 5 for Biphetamine 12.5. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Biphetamine 12.5 and Cuprimine?

Biphetamine 12.5 contains Amphetamine Resin Complex and Dextroamphetamine Resin Complex, while Cuprimine contains Penicillamine — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.