BETAPACE AF vs BRETYLOL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. BETAPACE AF and BRETYLOL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	BETAPACE AF	BRETYLOL
Rating	New	60/100
Pharmacy pays	~$2.96 /30	—
Type	RX	RX
Active ingredient	SOTALOL HYDROCHLORIDE	BRETYLIUM TOSYLATE
Manufacturer	Legacy Pharma	Hospira
Dosage forms	Tablet	Injectable
Drug class	Antiarrhythmic	—
Boxed warning	Boxed warning	None
Half-life	about 12 hours (the label gives a mean elimination half-life of 12 hours)	—
Treats	Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia	Ventricular Fibrillation, Ventricular Tachycardia

betapace af bretylol

Rating

New

60/100

Pharmacy pays

~$2.96 /30

—

Type

Active ingredient

SOTALOL HYDROCHLORIDE

BRETYLIUM TOSYLATE

Manufacturer

Legacy Pharma

Hospira

Dosage forms

Tablet

Injectable

Drug class

Antiarrhythmic

—

Boxed warning

None

Half-life

about 12 hours (the label gives a mean elimination half-life of 12 hours)

—

Treats

Atrial Fibrillation, Atrial Flutter, Supraventricular Tachycardia

Ventricular Fibrillation, Ventricular Tachycardia

Frequently asked questions

What is the difference between Betapace Af and Bretylol?

Betapace Af contains Sotalol Hydrochloride, while Bretylol contains Bretylium Tosylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.