BETADINE vs E-Z PREP 220

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Attribute	BETADINE	E-Z PREP 220
Rating	New	New
Pharmacy pays	$0.02 /mL	$0.02 /mL
Type	RX	RX
Active ingredient	POVIDONE-IODINE	POVIDONE-IODINE
Manufacturer	Alcon	Clinipad
Dosage forms	Solution, Spray/Inhaler	Sponge
Drug class	—	—
Boxed warning	None	None
Treats	Burns, Leg Ulcer, Radiation Injuries	Burns, Leg Ulcer, Radiation Injuries

betadine e-z prep 220

Rating

New

Pharmacy pays

$0.02 /mL

Type

Active ingredient

POVIDONE-IODINE

Manufacturer

Alcon

Clinipad

Dosage forms

Solution, Spray/Inhaler

Sponge

Drug class

—

Boxed warning

None

Treats

Burns, Leg Ulcer, Radiation Injuries

Frequently asked questions

Which is cheaper, Betadine or E-Z Prep 220?

Pharmacies pay about the same to acquire either one — roughly $0.02 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Betadine and E-Z Prep 220?

Both Betadine and E-Z Prep 220 share the active ingredient Povidone-Iodine.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.